[New paper] An open-source ensemble framework for accurate cell calling in targeted single-cell DNA sequencing.

Our new paper has been published in Bioinformatics.

 In this paper, Taehyeon Kim developed CellSavior, an open-source cell calling tool for targeted single-cell DNA sequencing. It combines ensemble clustering across several distance metrics with confidence-weighted consensus. Across 33 datasets it matched the commercial software’s results in 31 cases (93.9%). In the cases where they disagreed, it recovered cell clusters that had been missed, and those clusters were enriched for key hotspot mutations.

Kim T, Chung YS, Park D, Oh S, Shim JK, Cho H, Kang SG, Kim S. CellSavior: an open-source framework for improved cell calling in targeted single-cell DNA sequencing. Bioinformatics. 2026. doi.org/10.1093/bioinformatics/btag808

Collaboration with Prof. Seok-Gu Kang (Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine)

Congratulations!