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[New paper] The role of HLA-I-restricted CD8+ T cell immunity with VHL inactivation during early tumorigenesis

Our new paper has been published in iScience.

In this paper, we demonstrate that while CD8+ T cells efficiently target HLA-I antigen-presenting tumor cells in early stages, the effectiveness varies with antigen recognition and is complicated by VHL gene inactivation, which, through an unexpected association with HLA-I heterozygosity, can accelerate tumor development, potentially due to VEGF-A-mediated T cell exhaustion.


Park, BeumJin, et al. "HLA-I-restricted CD8+ T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation." Iscience 25.6 (2022).


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