[New paper] The role of HLA-I-restricted CD8+ T cell immunity with VHL inactivation during early tumorigenesis

Our new paper has been published in iScience.

In this paper, we demonstrate that while CD8+ T cells efficiently target HLA-I antigen-presenting tumor cells in early stages, the effectiveness varies with antigen recognition and is complicated by VHL gene inactivation, which, through an unexpected association with HLA-I heterozygosity, can accelerate tumor development, potentially due to VEGF-A-mediated T cell exhaustion.

Congratulations!

Park, BeumJin, et al. "HLA-I-restricted CD8+ T cell immunity may accelerate tumorigenesis in conjunction with VHL inactivation." Iscience 25.6 (2022).

https://doi.org/10.1016/j.isci.2022.104467