[New paper] Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer

Our new paper has been published in EBioMedicine.

In this paper, in collaboration with Prof. Seungmin Bang (Yonsei), Prof. Hee Seung Lee (Yonsei) established patient-derived model of PDAC and perform genetic analysis with responses to anticancer drug by using the conditionally reprogrammed cell (CRC) methodology. We investigated genetic profiles including mutation patterns and copy number variations using targeted deep sequencing and RNA sequencing. We assessed the responses of cultured CRCs to the available clinical anticancer drugs based on patient responsiveness. We found that somatic mutations were shared in the primary-CRC pairs and shared mutations included key oncogenic mutations.We show that a pancreatic cancer cell line model can be efficiently established using the CRC methodology, to better support a personalized therapeutic approach for pancreatic cancer patients.

This study has been mainly done by Eunyoung Kim and Sangwoo Kim. Se-Young Jo participated in the study as authors.

Congratulations!

Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer. EBioMedicine, 2021, Mar:65:103218, https://doi.org/10.1016/j.ebiom.2021.103218