[New paper] Impact of mouse contamination in genomic profiling of patient-derived models and best pr
- sak042
- Nov 11, 2019
- 1 min read
Our new paper has been published in Genome Biology.
In this study, we showed the impacts of mouse genome contamination occurring the analysis of human PDM sequencing data, and suggested the best practice for robust analysis.
Sangwoo Kim and Eunyoung Kim initiated the key idea, and Eunyoung Kim prepared the benchmark dataset. Se-Young Jo conducted the main analysis through the study with Sangwoo Kim's supervision.
Jo, S., Kim, E. & Kim, S. Impact of mouse contamination in genomic profiling of patient-derived models and best practice for robust analysis. Genome Biol 20, 231 (2019) doi:10.1186/s13059-019-1849-2


![[Media cover] Dr. Junho Kim appeared in BRIC homepage](https://static.wixstatic.com/media/445be0_92e55fd8503243c0b39bd11e32b70c78~mv2.png/v1/fill/w_447,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_92e55fd8503243c0b39bd11e32b70c78~mv2.webp)
![[Media cover] Dr. Junho Kim appeared in BRIC homepage](https://static.wixstatic.com/media/445be0_92e55fd8503243c0b39bd11e32b70c78~mv2.png/v1/fill/w_220,h_123,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_92e55fd8503243c0b39bd11e32b70c78~mv2.webp)
![[New paper] New model for calling low-level somatic mutations](https://static.wixstatic.com/media/445be0_98fe336b355d4de7969f74b807056e1d~mv2.png/v1/fill/w_447,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_98fe336b355d4de7969f74b807056e1d~mv2.webp)
![[New paper] New model for calling low-level somatic mutations](https://static.wixstatic.com/media/445be0_98fe336b355d4de7969f74b807056e1d~mv2.png/v1/fill/w_220,h_123,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_98fe336b355d4de7969f74b807056e1d~mv2.webp)
![[Award] Prof. Sangwoo Kim won the 5th Amgen-KAST Biotechnology Award from the Korean Academy of Science and Technology (KAST)](https://static.wixstatic.com/media/445be0_6a700e498873459eac095d6931050fac~mv2.jpg/v1/fill/w_440,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/445be0_6a700e498873459eac095d6931050fac~mv2.webp)
![[Award] Prof. Sangwoo Kim won the 5th Amgen-KAST Biotechnology Award from the Korean Academy of Science and Technology (KAST)](https://static.wixstatic.com/media/445be0_6a700e498873459eac095d6931050fac~mv2.jpg/v1/fill/w_74,h_42,fp_0.50_0.50,q_90,enc_avif,quality_auto/445be0_6a700e498873459eac095d6931050fac~mv2.webp)
![[Award] Taehyeon Kim won BIOINFO 2025 Excellent Poster Award from the Korean Society for Bioinformatics (KSBI)](https://static.wixstatic.com/media/445be0_d28d626f4324465c9e9a51a67131f94a~mv2.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/445be0_d28d626f4324465c9e9a51a67131f94a~mv2.webp)
![[Award] Taehyeon Kim won BIOINFO 2025 Excellent Poster Award from the Korean Society for Bioinformatics (KSBI)](https://static.wixstatic.com/media/445be0_d28d626f4324465c9e9a51a67131f94a~mv2.jpg/v1/fill/w_74,h_74,fp_0.50_0.50,q_90,enc_avif,quality_auto/445be0_d28d626f4324465c9e9a51a67131f94a~mv2.webp)
![[News] Celebrating Our Alumna: Dr. Yoo-Jin Ha Joins Hanyang University as a Professor](https://static.wixstatic.com/media/445be0_f9868047493140be95e8d6d45b574425~mv2.png/v1/fill/w_285,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_f9868047493140be95e8d6d45b574425~mv2.webp)
![[News] Celebrating Our Alumna: Dr. Yoo-Jin Ha Joins Hanyang University as a Professor](https://static.wixstatic.com/media/445be0_f9868047493140be95e8d6d45b574425~mv2.png/v1/fill/w_74,h_65,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_f9868047493140be95e8d6d45b574425~mv2.webp)
![[Award] Ahyeon Kim won the Research Support Scholarship from the Health Fellowship Foundation (HFF)](https://static.wixstatic.com/media/445be0_eed364dcfe4047dfa6644808d046c2bb~mv2.png/v1/fill/w_171,h_224,fp_0.50_0.50,lg_1,q_35,blur_30,enc_avif,quality_auto/445be0_eed364dcfe4047dfa6644808d046c2bb~mv2.webp)
![[Award] Ahyeon Kim won the Research Support Scholarship from the Health Fellowship Foundation (HFF)](https://static.wixstatic.com/media/445be0_eed364dcfe4047dfa6644808d046c2bb~mv2.png/v1/fill/w_74,h_97,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_eed364dcfe4047dfa6644808d046c2bb~mv2.webp)
![[Media cover] Taek Chung’s research covered in media](https://static.wixstatic.com/media/445be0_e2366087f3ee42dbb47a742af6016908~mv2.png/v1/fill/w_440,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_e2366087f3ee42dbb47a742af6016908~mv2.webp)
![[Media cover] Taek Chung’s research covered in media](https://static.wixstatic.com/media/445be0_e2366087f3ee42dbb47a742af6016908~mv2.png/v1/fill/w_74,h_42,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_e2366087f3ee42dbb47a742af6016908~mv2.webp)
![[New paper] Carcinogenic sequence uncovered at the genomic and transcriptomic levels in biliary tract cancer](https://static.wixstatic.com/media/445be0_71f38d7e682142adb88dfc5102a6c73d~mv2.png/v1/fill/w_440,h_250,fp_0.50_0.50,lg_1,q_35,blur_30,enc_avif,quality_auto/445be0_71f38d7e682142adb88dfc5102a6c73d~mv2.webp)
![[New paper] Carcinogenic sequence uncovered at the genomic and transcriptomic levels in biliary tract cancer](https://static.wixstatic.com/media/445be0_71f38d7e682142adb88dfc5102a6c73d~mv2.png/v1/fill/w_74,h_42,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_71f38d7e682142adb88dfc5102a6c73d~mv2.webp)
![[Published in Nature] Meningomyelocele Linked to De Novo Genetic Mutations, According to Landmark Study](https://static.wixstatic.com/media/445be0_20fa3d5737964fdcbf6a1f0a0dc2eceb~mv2.png/v1/fill/w_440,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_20fa3d5737964fdcbf6a1f0a0dc2eceb~mv2.webp)
![[Published in Nature] Meningomyelocele Linked to De Novo Genetic Mutations, According to Landmark Study](https://static.wixstatic.com/media/445be0_20fa3d5737964fdcbf6a1f0a0dc2eceb~mv2.png/v1/fill/w_74,h_42,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_20fa3d5737964fdcbf6a1f0a0dc2eceb~mv2.webp)
![[New paper] Reversion of BRCA1 L1780P mutation confers resistance to PARP and ATM inhibitors in breast cancer](https://static.wixstatic.com/media/445be0_c80a6fb2c75e474a80d7882264800d60~mv2.png/v1/fill/w_250,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_c80a6fb2c75e474a80d7882264800d60~mv2.webp)
![[New paper] Reversion of BRCA1 L1780P mutation confers resistance to PARP and ATM inhibitors in breast cancer](https://static.wixstatic.com/media/445be0_c80a6fb2c75e474a80d7882264800d60~mv2.png/v1/fill/w_74,h_74,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_c80a6fb2c75e474a80d7882264800d60~mv2.webp)
![[Award] Yoo-Jin Ha awarded The 14th Dissertation of the Year Award (Biological Science) from the Korean Academy of Science and Technology, funded by The S-OIL Science and Culture](https://static.wixstatic.com/media/445be0_c83776be76b64949bae81e77ed5433de~mv2.png/v1/fill/w_385,h_250,fp_0.50_0.50,q_35,blur_30,enc_avif,quality_auto/445be0_c83776be76b64949bae81e77ed5433de~mv2.webp)
![[Award] Yoo-Jin Ha awarded The 14th Dissertation of the Year Award (Biological Science) from the Korean Academy of Science and Technology, funded by The S-OIL Science and Culture](https://static.wixstatic.com/media/445be0_c83776be76b64949bae81e77ed5433de~mv2.png/v1/fill/w_74,h_48,fp_0.50_0.50,q_95,enc_avif,quality_auto/445be0_c83776be76b64949bae81e77ed5433de~mv2.webp)
![[Award] Jeongsoo Won won best poster award in BIOINFO 2024](https://static.wixstatic.com/media/445be0_c70a449b1e73476fb55ac9955da13682~mv2.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_avif,quality_auto/445be0_c70a449b1e73476fb55ac9955da13682~mv2.webp)
![[Award] Jeongsoo Won won best poster award in BIOINFO 2024](https://static.wixstatic.com/media/445be0_c70a449b1e73476fb55ac9955da13682~mv2.jpg/v1/fill/w_74,h_74,fp_0.50_0.50,q_90,enc_avif,quality_auto/445be0_c70a449b1e73476fb55ac9955da13682~mv2.webp)


