CONTACT INFORMATION  

Postdoctoral Researcher

Translational Genome Informatics Laboratory

Dept. of Biomedical Systems Informatics

Yonsei University College of Medicine

50-1 Yonsei-ro, Seodaemun-gu,

Seoul 03722, South Korea.

Office: +82-2-2228-2488

  RESEARCH AREAS  

Genome analysis, Bioinformatics, NGS analysis method development, Scientific databases

  EDUCATION  

2001.3.-2007.8.    

1999.3.-2001.2.

1995.3.-1999.2.

 

 

Ph. D.    

MS

BS

Biochemistry (Structural Biology)    

Biochemistry (Structural Biology)

Biotechnology

Korea University

Korea University

Korea University

  ACADEMIC EXPERIENCES  

2018.3.-present    

2014.12.-2018.2    
2011.3.-2014.2    
2010.3.-2011.2    
2008.6.-2010.2    
2007.9.-2008.5    

Postdoctoral Researcher    

Postdoctoral Researcher    
Research Assistant Professor
Instructor
Senior Researcher
Postdoctoral Researcher

Dept. of Biomedical Systems Informatics

Yonsei Biomedical Science Institute
Dept. of Forensic Science
Dept. of Forensic Science
Div. of Influenza Viruses
Dept. Biotechnology & Bioinformatics    

Yonsei University   

Yonsei University   
Yonsei University
Yonsei University
KNIH, KCDC
Korea University

  PUBLICATIONS  

Journals (Pear Reviewed; SCI)

  1. Gunho Lee, Hyang Joo Ryu, Ji Woon Choi, Hyundeok Kang, Woo Ick Yang, In Seok Yang, Mi-Kyoung Seo, Sangwoo Kim, Sun Och Yoon. Characteristic gene alterations in primary gastrointestinal T and NK cell lymphomas. Leukemia (2019) In press

  2. In Seok Yang, Sangwoo Kim. Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients. BMC Bioinformatics. (2018) 19(Suppl 1): 40

  3. Choong-kun Lee, Sora Kim, Jae Seok Lee, Jeong Eun Lee, Sung-moo Kim, In Seok Yang, Hye Ryun Kim, Jeong Ho Lee, Sangwoo Kim, Byoung Chul Cho. Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIs. Lung Cancer. (2017) 113, 106-114.

  4. In Seok Yang, Hyeonju Son, Sora Kim, Sangwoo Kim. ISOexpresso: a web-based platform for isoform-level expression analysis in human cancer. BMC Genomics. (2016) 17(1), 631.

  5. Sun Min Lim, Hyung Soon Park, Sangwoo Kim, Sora Kim, Siraj. M. Ali, Joel. R. Greenbowe, In Seok Yang, Nak-Jung Kwon, Jae Lyun Lee, Min-Hee Ryu, Jin-Hee Ahn, Jeeyun Lee, Min Goo Lee, Hyo Song Kim, Hyunki Kim, Hye Ryun Kim, Yong Wha Moon, Hyun Cheol Chung, Joo-Hang Kim, Yoon-Koo Kang and Byoung Chul Cho. Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus. Oncotarget. (2016) 7(9), 10547-10556.

  6. Eun Young Lee, Hwan Young Lee, Se Yoon Oh, Sang-Eun Jung, In Seok Yang, Yang-Han Lee, Woo Ick Yang, Kyoung-Jin Shin. Massively parallel sequencing of the entire control region and targeted coding region SNPs of degraded mtDNA using a simplified library preparation method. Forensic Sci Int Genet. (2016) 22, 37-43.

  7. Eun Hye Kim, Hwan Young Lee, In Seok Yang, Sang-Eun Jung, Woo Ick Yang, Kyoung-Jin Shin. Massively parallel sequencing of 17 commonly used forensic autosomal STRs and amelogenin with small amplicons. Forensic Sci Int Genet. (2016) 22, 1-7.

  8. Eun Hye Kim, Hwan Young Lee, In Seok Yang, Woo Ick Yang, Kyoung-Jin Shin. Population data for 30 insertion-deletion markers in a Korean population. Int J Legal Med. (2014) 128(1), 51-52.

  9. In Seok Yang, Hwan Young Lee, Woo Ick Yang, Kyoung-Jin Shin. mtDNAprofiler: a Web application for the nomenclature and comparison of human mitochondrial DNA sequences. J Forensic Sci. (2013) 58(4), 972-980.

  10. Allah Rakha, Kyoung-Jin Shin, Jung Ah Yoon, Na Young Kim, Muhammad Hassan Siddique, In Seok Yang, Woo Ick Yang, Hwan Young Lee. Forensic and genetic characterization of mtDNA from Pathans of Pakistan. Int J Legal Med. (2011) 125(6), 841-848.

  11. In Seok Yang, Tae Gyun Kim, Bum Seok Park, Ki Joon Cho, Ji-Hye Lee, Yiho Park, Kyung Hyun Kim. Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding. Biochem Biophys Res Commun. (2010) 397, 429–435. (Co-first author)

  12. Seokha Kang, In Seok Yang, Joo-Yeon Lee, Yiho Park, Hee-Bok Oh, Chun Kang, Kyung Hyun Kim. Epidemiologic Study of Human Influenza Virus Infection in South Korea from 1999 to 2007: Origin and Evolution of A/Fujian/411/2002-Like Strains. J Clin Microbiol. (2010) 48, 2177-85. (Co-first author)

  13. Woo-Young Choi, Su Jin Kim, Nam Joo Lee, Meehwa Kwon, In Seok Yang, Min-Ji Kim, Seul-Gi Cheong, Donghyok Kwon, Joo-Yeon Lee, Hee-Bok Oh, Chun Kang. Amantadine-resistant influenza A viruses isolated in South Korea from 2003-2009. Antiviral Res. (2009) 84, 199-202.

  14. In Seok Yang, Joo-Yeon Lee, Joon Seung Lee, Wayne P. Mitchell, Hee-Bok Oh, Chun Kang, Kyung Hyun Kim. Influenza sequence and epitope database. Nucleic Acids Res. (2009) 37, D423-D430.

  15. In Seok Yang, Chunsun Ryu, Ki Joon Cho, Jin Kwang Kim, Swee Hoe Ong, Wayne P. Mitchell, Bong-Su Kim, Hee-Bok Oh, Kyung Hyun Kim. IDBD: Infectious Disease Biomarker Database. Nucleic Acids Res. (2008) 36, D455 - D460.

  16. Kim, So-Young, Jung-Hoon Sohn, Yu-Ryang Pyun, In Seok Yang, Kyung Hyun Kim, Eui-Sung Choi. In vitro evolution of lipase B from Candida antarctica using surface display in Hansenula polymorpha. J. Microbiol. Biotechnol. (2007) 17, 1308-1315.

  17. Ji-Hye Lee, Jin Sun Shim, Jung Sun Lee, Jin Kwang Kim, In Seok Yang, Mi-Sook Chung, Kyung Hyun Kim. Inhibition of pathogenic bacterial adhesion by acidic polysaccharide from green tea (Camellia sinensis). J. Agri. Food Chem. (2006) 54, 8717-8723.

  18. Jin Kwang Kim, In Seok Yang, Hye Jeong Shin, Ki Joon Cho, Eui Kyung Ryu, Sun Hwa Kim, Sung Soo Park, Kyung Hyun Kim. Insight into autoproteolytic activation from the structure of cephalosporin acylase. Proc. Natl. Acad. Sci. USA. (2006) 103, 1732-1737. (Co-first author)

  19. Jin Ah Yang, Dae Won Park, Jang Wook Sohn, In Seok Yang, Kyung Hyun Kim, Min Ha Kim. Molecular analysis of isoleucyl-tRNA synthetase mutations in clnical isolates of methicillin-resistant Staphylococcus aureus with low-level mupirocin resistance. J. Kor. Med. Sci. (2006) 21, 827-832.

  20. Jin Kwang Kim, In Seok Yang, Sangkee Rhee, Zbigniew Dauter, Young Sik Lee, Sung Soo Park, Kyung Hyun Kim. Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: Insight into autoproteolytic activation. Biochemistry (2003) 42, 4084-4093

 

 

Journals (Pear Reviewed; non-SCI)

  1. In Seok Yang and Sangwoo Kim. Analysis of Whole Transcriptome Sequencing Data: Workflow and Software. Genomics Inform. (2015) 13(4), 119-25.

  2. Eun Hye Kim, Sang-Eun Jung, Kyoung-Jin Shin, Woo Ick Yang, In Seok Yang. Sequence generation and genotyping of 15 autosomal STR markers using next generation sequencing. Korean J Leg Med. (2014) 38(2), 48-58. (Corresponding author)

  3. In Seok Yang, Hwan Young Lee, Su Jeong Park, Woo Ick Yang, Kyoung-Jin Shin. Analysis of Kinship Index Distributions in Koreans Using Simulated Autosomal STR Profiles. Korean J Legal Med. (2013) 37(2), 57-65.

  4. In Seok Yang, Hwan Young Lee, Myung Jin Park, Woo Ick Yang, Kyoung-Jin Shin. Web-based Y-STR Database for Haplotype Frequency Estimation and Kinship Index Calculation. Korean J Legal Med. (2012) 36, 45-55.

  5. Woo-Young Choi, In Seok Yang, Sujin Kim, Namjoo Lee, Meehwa Kwon, Joo-Yeon Lee, Chun Kang. The Emergence of Oseltamivir-ResistantSeasonalInfluenzaA (H1N1) Virus in Korea During the 2008–2009 Season. Public Health Res Perspect. (2011) 2(3), 178-185. (Co-first author)

 

 

Conference Proceedings and Presentations

  1. In Seok Yang, Sangwoo Kim. Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients. BMC Bioinformatics. Oral presentation (GIW 8 - Cancer Bioinformatics, p58) at 2-17 GIW/BIOINFO Annual Conference, Seoul, Korea. Oct 31-Nov 3, 2017.

  2. In Seok Yang, Hyeonju Son, Sora Kim, Sangwoo Kim. ISOexpresso: Isoform Expression Resource for Tissue-specific Variant Annotation. Poster (A-003) at BIOINFO 2015, Korean Society for Bioinformatics and System Biology, Seoul, Korea. Oct 21-23, 2015.

  3. In Seok Yang, Hyeonju Son, Sora Kim, Sangwoo Kim. ISOexpresso: Isoform Expression Resource for Tissue-specific Variant Annotation. Poster (I-12) at The 24th KOGO Annual Conference 2015. Seoul, Korea. Sept 9-11, 2015.

  4. Kyoung-Jin Shin, Eun Hye Kim, In Seok Yang, Sang-Eun Jung, Hwan Young Lee. A new multiplex PCR system for forensic STR profiling using next generation sequencing. Presentation (O7) at DNA in Forensics 2014. Brussels, Belgium. May 14, 2014.

  5. Eun Hye Kim, Sang-Eun Jung, In Seok Yang, Kyoung-Jin Shin. Development and application of second generation sequencing panel for forensic STR profiling. Presentation at 2014 International Symposium on Forensic DNA in Law. Seoul, Korea. February 28, 2014.

  6. Eun Hye Kim, Sang-Eun Jung, Kyoung-Jin Shin, Su Jeong Park, Seung Hwan Lee, In Seok Yang. Effective genotyping strategy of forensic short tandem repeat using next generation sequencing. Poster (A58) at 66th American Academy of Forensic Sciences. Seattle, WA, USA. February 19-21, 2014. (Corresponding author)

  7. In Seok Yang. Effective genotyping strategy of forensic short tandem repeat using next generation sequencing. Presentation at The 10th KOGO Winter Symposium. Pyeongchang, Korea. Feb 7, 2014.

  8. In Seok Yang, Eun Hye Kim, Kyoung-Jin Shin. Amplicon preparation and data analysis for autosomal STR profiling using next generation sequencing. Poster (PE 8) at The 27th Conference of Korean Society of Forensic Sciences. Seoul, Korea. June 14, 2013.

  9. In Seok Yang, Hwan Young Lee, Su Jeong Park, Woo Ick Yang, Kyoung-Jin Shin. Analysis of kinship index distributions in Koreans using simulated autosomal STR profiles. Presentation at 18th Spring Meeting of the Korean Society for Legal Medicine. Seoul, Korea. May 31, 2013.

  10. Eun Hye Kim, Hwan Young Lee, In Seok Yang, Woo Ick Yang, Kyoung-Jin Shin. A population study for 30 insertion-deletion markers in a Korean population. Poster (Y-15-158) at 2013 Annual Meeting of Korean Society for Biochemistry and Molecular Biology. Seoul, Korea. May 15, 2013.

  11. In Seok Yang, Hwan Young Lee, Myung Jin Park, Woo Ick Yang, Kyoung-Jin Shin. Web-based Y-STR database for haplotype frequency estimation and kinship index calculation. Presentation at 17th Spring Meeting of the Korean Society for Legal Medicine. Gwangju, Korea. May 25, 2012.

  12. In Seok Yang, Hwan Young Lee, Woo Ick Yang, Kyoung-Jin Shin. mtDNAprofiler: a web-based program for nomenclature and comparison of mtDNA sequences. Presentaion at 34th Annual Meeting of the Korean Society for Legal Medicine. Seoul, Korea. November 26, 2010.

  13. In Seok Yang, Hwan Young Lee, Woo Ick Yang, Kyoung-Jin Shin. mtDNAprofiler: a web-based mitochondrial DNA sequence analyzer. October 11-14, 2010. 21th International Symposium on Human Identification. San Antonio, Texas, USA.

  14. In Seok Yang, Joo-Yeon Lee, Woo-Young Choi, Jeong Sun Yang, Yoon Seok Cung, Jang Hoon Choi, Donghyok Kwon, Da Hyun Hwang, Eun Hye Hong, Su Jin Kim, Jin Young Shin, Hoon Chung, Nam Joo Lee, Wanji Lee, Seung Tae Kim, Hee Sook Yoon, Mi Seon Kim, Kyeong Cheol Shin, Ki Soon Kim, Hee-Bok Oh, Chun Kang. Genetic characteristics of pandemic (H1N1) 2009 influenza virus in Korea. October, 2009. The Federation of Korean Microbiological Societies International Conference. Seoul, Korea.

  15. In Seok Yang, Nam Joo Lee, Su Jin Kim, Woo-Young Choi, Chun Kang, Joo-Yeon Lee. Antigenic and molecular analysis of influenza A viruses isolated in Korea from 2007-2008 to 2008-2009 seasons. April, 2009. The Federation Meeting of Korean Basic Medical Sciences. Suwon, Korea.

  16. Su Jin Kim, Woo-Young Choi, In Seok Yang, Nam Joo Lee, Meehwa Kwon, Joo-Yeon Lee, Chun Kang. The first emergence of oseltamivir resistant influenza A/H1N1 virus in Korea during 2008-2009 season. April, 2009. The Federation Meeting of Korean Basic Medical Sciences. Suwon, Korea.

  17. Joon Seung Lee, In Seok Yang, Joo-Yeon Lee, Hee-Bok Oh, Chun Kang, Kyung Hyun Kim. Influenza Sequence and Epitope Database. October, 2008. The Federation of Korean Microbiological Societies International Conference. Seoul, Korea.

  18. In Seok Yang, Joo-Yeon Lee, Nam Joo Lee, Su Jin Kim, Woo-Young Choi, Chun Kang. Genetic analysis of influenza B virus in Korea, 2007-2008 season. October, 2008. The Federation of Korean Microbiological Societies International Conference. Seoul, Korea.

  19. In Seok Yang, Joo-Yeon Lee, Hee-Bok Oh, Chun Kang, Kyung Hyun Kim. Influenza Sequence and Epitope Database (ISED). September, 2008. Korea e-Science AHM. Daejeon, Korea.

  20. In Seok Yang, Chunsun Ryu, Bong-Su Kim, Hee-Bok Oh, Kyung Hyun Kim. Biomarker Database for Infectious Diseases. June, 2007. The Korean Society for Microbiology and Biotechnology International Conference. Seoul, Korea.

  21. Chunsun Ryu, Eun Jung Lee, Bong-Su Kim, Hee-Bok Oh, In Seok Yang, Jin Kwang Kim, Ki Joon Cho, Kyung Hyun Kim. Biomarker Database: a web-based biological information of infectious disease biomarkers. October, 2006. The Federation of Korean Microbiological Societies International Conference. Seoul, Korea.

  22. Jin Kwang Kim, In Seok Yang, Hye Jeong Shin, Ki Joon Cho, Eui Kyung Ryu, Sun Hwa Kim, Sung Soo Park, Kyung Hyun Kim. Structural insight into autoproteolytic activation based on cephalosporin acylase intermidiate structures. June, 2004. Korean Biochemical Society. Seoul, Korea.

  23. Jin Kwang Kim, In Seok Yang, Kyung Hyun Kim. Observation of conformation-specific intermediates in autoproteolytic activation. 2003. Korean Crystallographic Association. Daejeon, Korea.

  24. Jin Kwang Kim, In Seok Yang, Sangkee, Rhee, D. Zbigniew, Sung Soo Park, Kyung Hyun Kim. Crystal structure of glutaryl 7-aminocephalosporanic acid acylase from Pseudomonas sp. GK16. October, 2001. Korean Biochemical Society. Seoul, Korea.

  SKILLS  

Protein Structure Analysis

  • Protein structure analysis based on X-ray Crystallography

Database

  • Construction of scientific databases (IDBD, ISED, ySTRmanager, and ISOexpresso)

Omics-data analysis

  • Transcript-level RNA-seq data analysis (discovery, identification, and expression quantification of transcripts)

  • Functional prediction of amino-acid changes using known protein structure

Programming languages

  • Linux shell script

  • Perl

  • Python 2 and 3

  • C# (C shop)

  • VBA (Visual Basic for Application)

  • HTML (Hyper Text Markup Language)

  • PHP (Personal Hypertext Preprocessor)

  • JSP (Java Server Page)

  • JavaScript

  • SQL (Structured Query Language)

Last Update: May 29, 2019